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STEROID 12-ALPHA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 12-alpha-Hydroxylase
Descriptor
Spanish
:
Esteroide 12-alfa-Hidroxilasa
Descriptor
Portuguese
:
Esteróide 12-alfa-Hidroxilase
Synonyms
English
:
12-alpha-Hydroxylase
Steroid 12-Monooxygenase
Sterol 12-alpha-Hydroxylase
Tree Number:
D08.244.453.915.730
D08.811.682.690.708.170.915.730
D08.811.682.690.708.783.730
D12.776.422.220.453.915.730
Definition
English
:
A
liver
microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of
sterols
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of
BILE
ACIDS
from
cholesterol.
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
29288
Unique Identifier:
D013253
Occurrence in VHL
:
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